CFTR and asthma: Crespo-Lessman et al. showed that asthma phenotype with mucus hypersecretion may be related with an intronic polymorphism in the CFTR gene (NM_000492.3:c.1680-870T>A), and these patients may have a poorer clinical outcome characterized by severe disease and poorer asthma control with a non-allergic inflammatory phenotype [25].