Riolo et al. compared the clinical characteristics, including features of CFTR-related disorders and the prevalence of CFTR mutations in individuals with severe asthma and non-severe asthma, concluding that features of CFTR-related disorders (rhinosinusitis, nasal polyposis, and bronchiectasis) were more prevalent in severe asthma than non-severe asthma, while 11% of severe asthma patients had CFTR mutations, suggesting a possible association between CFTR mutations and asthma severity [26]. The gene discussed is CFTR; the disease is Nasal polyposis.