Estradiol levels provide a significant predictor for affective disorders in adolescents with endometriosis before treatment (STAI reactive anxiety; HADS anxiety/depression; McGill affective/constant pain score) and after the therapy (STAI and HADS anxiety scores), whereas BMI and CRP levels are, respectively, negative and positive factors of pain syndrome severity. The gene discussed is CRP; the disease is depressive symptom measurement.