The main clinical features are asthmatic symptoms, mucus plugging, pulmonary opacities, bronchiectasis, lung fibrosis, elevated blood eosinophils count and total serum IgE, and detectable serum IgE or precipitating serum antibodies against Aspergillus fumigatus or aspergillus skin test positivity [13,14]. Here, IGHE is linked to pulmonary fibrosis.