However, these associations are contentious as Lerbaek et al. [14] and Carlsen et al. [15] noted no association between the filaggrin null alleles and hand eczema, but the former acknowledged that this could be due to insufficient statistical power, and the latter recognized that such mutation(s) could, nevertheless, have an impact on certain sub-types of hand eczema, such as in the context of irritant hand dermatitis. Here, FLG is linked to hand eczema.