ENHO and hydrops fetalis: The main causes of changeable levels of adropin in HF might be a suppression of adropin synthesis and release due to inflammatory and neurohumoral activation in connection with concomitant circulatory deficiency and subsequent tissue ischemia/hypoxia, poor kidney clearance of adropin, declining skeletal muscle mass and adipose mass tissue, malabsorption and failed digestion of nutrients, and psychological problems [67].