There is restrictive evidence of the reproducibility and predictability of conventional kidney injury biomarkers, including albuminuria, proteinuria, albumin/creatinine ratio, eGFR, cystatin C, as well as cardiac biomarkers (natriuretic peptides, cardiac troponins) for CKD in HF patients with concomitant T2DM [45,46]. This evidence concerns the gene CST3 and chronic kidney disease.