An immunohistochemical study investigating 22 NAMs, 20 non-NAM acral melanomas, and 14 benign acral nevi reported that 73% of NAMs, 95% of non-NAM acral melanomas were positive for PRAME at least in part, whereas only one (7%) acral nevus exhibited PRAME expression [38]. The gene discussed is PRAME; the disease is acral lentiginous melanoma.