IGHE and allergic disease: In 2003, the Nomenclature Review Committee of the World Allergy Organization proposed a new nomenclature for allergies in which the term “atopy’’ refers to a genetic predisposition to become immunoglobulin E (IgE) sensitized to allergens commonly found in the environment to which everyone is exposed but to which most people do not produce a long-term IgE antibody response [4].