A study based on a large cohort of 1306 patients identified some mutations (in IDH1, ASXL1, and SRSF2), unfavorable karyotype, elderly age, male sex, rate of peripheral blood blasts ≥ 3%, moderate or severe anemia, and constitutional symptoms as variables correlated to a leukemic transformation within 5 years [42]. This evidence concerns the gene IDH1 and anemia (phenotype).