Adults with atopic dermatitis exhibit SA hyperresponsiveness, resulting in the transient release of cortisol from the adrenal glands into the bloodstream, while corticotrophin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH) and cortisol from skin cells are released, which favor the Th2 response and inhibit the Th1 response. The gene discussed is POMC; the disease is atopic eczema.