The GAME score was calculated by allocating points to each patient according to the presence of these predictive factors: KRAS-mutated tumors (1 point); carcinoembryonic antigen level 20 ng/mL or more (1 point), primary tumor lymph node metastasis (1 point); a tumor burden score between 3 and 8 (1 point) or 9 and over (2 points); and extrahepatic disease (2 points). Here, KRAS is linked to neoplasm.