Over the past two decades, many studies conducted in populations without a history of atherosclerotic cardiovascular disease (ASCVD), including observational studies, meta-analyses, mendelian randomization studies, and genome-wide association studies, have shown that high levels of Lp(a) are linearly associated with an increased risk of developing ASCVD [53,54,55,56,57]. Here, LPA is linked to atherosclerosis.