TNFRSF4 and acute graft versus host disease: Furthermore, Tripathi et al. discovered in 2019 that the OX40L(TNFSF4)-OX40 interaction on T cells was linked to the induction and development of acute GVHD (aGVHD) in HSCT, and that treatment with anti-human OX40L mAb could effectively prevent and reduce the severity of aGVHD [36].