Most of the proteins involved as being essential in the progression of type 2 diabetes include glucokinase, insulin receptor substrate, 11-hydroxysteroid dehydrogenase, dipeptidyl peptidase IV, interleukin 1 beta, AMP-activated protein kinase, peroxisome proliferator-activated receptor gamma, C-reactive protein, glutamine fructose-6-phosphate amidotransferase, tyrosine kinase insulin receptor, insulin receptor, protein tyrosine phosphatases, and protein kinase B [6]. This evidence concerns the gene INSR and type 2 diabetes mellitus.