GPX4 and osteosarcoma: Lv et al. [50] concluded that PEITC was found to inhibit K7M2 bone marrow osteosarcoma cells, induce oxidative stress, GSH inactivation, increase MDA and ROS, and decrease GPX4, and it was considered that PEITC activated the MAPK signaling pathway, and ROS generation was the main cause of PEITC-induced cell death.