Liu et al. [52] found that GPX4 was highly expressed in resistant osteosarcoma cells by measuring ferroptosis-related proteins in cisplatin-resistant osteosarcoma cells, and promoting the occurrence of ferroptosis through ferroptosis inducers enhanced the sensitivity of osteosarcoma cells to cisplatin; meanwhile, further studies found that the reduction in GPX4 and the increase in ROS could correspondingly improve the sensitivity of resistant osteosarcoma cells to cisplatin. This evidence concerns the gene GPX4 and osteosarcoma.