The Factor V Leiden G1691A mutation (FVL) [10], prothrombin G20210A polymorphism (FIIG20210A) [11], non-O blood types (non-O BT) of the ABO blood type system [12], MTHFRnt677TT mutation [13], and male sex [14] have been suggested to accelerate the progression of liver fibrosis [9,15]. Here, F5 is linked to Hepatic fibrosis.