In another study, SET domain-containing protein 8 (SETD8) overexpression reduced hyperglycemia-induced IL-1β and IL-18 expression by attenuating hyperglycemia-induced MARK4 expression and inactivating the NLRP3 inflammasome, whereas H4K20me1, a downstream target of SETD8, was enriched in the MARK4 promoter region in HUVECs [100]. This evidence concerns the gene IL18 and Hyperglycemia.