Hyperglycemia increased levels of KMT6A, resulting in the enrichment of H3K27me3 at the deptor promoter leading to decreased deptor expression, which led to the activation of mTORC1 and mTORC2, controlled mesangial cell hypertrophy and FN and PAI-1 expression [96]. The gene discussed is SERPINE1; the disease is Hyperglycemia.