NFKB1 and diabetic kidney disease: The nucleotide binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome, by interacting with the mitogen-activated protein kinase (MAPK), induces oxidative stress, NF-κB signaling pathways and inflammatory factors, thus resulting in impaired kidney functioning and structural changes that culminate in DKD development and progression [21].