The levels of H4K20me1, a downstream target of KMT5A, decreased in hyperglycemia-treated HUVECs and the levels of H4K20me1 were enriched in the promoter region of enolase 1 (ENO1), regulating the ENO1 levels and thereby inducing EndMT [104]. This evidence concerns the gene KMT5A and Hyperglycemia.