In another study, KMT6A downregulated TxnIP expression through H3K27me3 enrichment in the promoter region of the transcription factor paired box 6 (Pax6), whereas the depletion of KMT6A led to an increase in the hyperglycemia-induced reactive oxygen species (ROS) levels and cellular death [98]. The gene discussed is TXNIP; the disease is Hyperglycemia.