In patients with diabetes, the hsCRP-lowering effect of SGLT2 inhibitors is weaker than that of GLP-1 receptor agonists, which also provide cardiovascular protection [75]; SGLT2 inhibitors are significantly more effective than GLP-1 receptor agonists in improving renal prognosis and preventing heart failure in diabetes, but they are less effective in suppressing atherosclerotic cardiovascular events. This evidence concerns the gene GLP1R and diabetes mellitus.