Surprising is that simply blocking SGLT2, one transporter in the PTECs of the kidney can stop the vicious cycle in cardiorenal anemia iron deficiency syndrome with or without diabetes, showing that excessive Na+/glucose influx into the PTECs via SGLT2 is central to the onset and progression of this multiorgan pathophysiological continuum. The gene discussed is SLC5A2; the disease is diabetes mellitus.