REST and sarcoma: Neuron-restrictive silencer factor (NRSF) was significantly upregulated in the injury-related DRGs of partial ligation of the sciatic nerve [113] and sarcoma-inoculated murine model [114], combining with the targeted Oprm1 gene in a sequence-specific manner and reducing the expression of the latter via HDAC-involved mechanisms [113], which is one of their main functions in regulating gene transcription.