In line with this, the NF-kB pathway is involved in many systemic hematological malignancies such as chronic lymphocytic leukemia (CLL), mucous membrane-associated lymphoma (MALT), diffuse large B-cell lymphoma (DLBCL) and acute lymphoblastic leukemia (ALL) [37]. This evidence concerns the gene NFKB1 and diffuse large B-cell lymphoma.