In line with this, the NF-kB pathway is involved in many systemic hematological malignancies such as chronic lymphocytic leukemia (CLL), mucous membrane-associated lymphoma (MALT), diffuse large B-cell lymphoma (DLBCL) and acute lymphoblastic leukemia (ALL) [37]. The gene discussed is NFKB1; the disease is acute lymphoblastic leukemia.