Both uc.48+ and NONRATT021972 knockdown has also been reported to suppress excitatory transmission mediated by the P2X3 receptor in the DRG, and their knockdown reduced the level of tumor necrosis factor-α (TNF-α) in the serum, leading to alleviation of hyperalgesia in DM rats [49,50,104]. This evidence concerns the gene TNF and diabetes mellitus.