Figure 5A reveals significant correlations between active RIPK2 and active AMPK and active YAP; significant correlations between RASSF1A expression and active RIPK2, active YAP, and active AMPK, suggesting an interplay of these four molecular drivers of inflammation, leading to metabolic and proliferative changes in the colon of IBD patients. This evidence concerns the gene PRKAA1 and irritable bowel syndrome.