Mahmoud et al. [171] demonstrated that novel polymethoxylated chalcones increased CRC cell apoptosis, inhibited angiogenesis and reduced the invasiveness and metastatic potential of CRC cells via downregulation of several epithelial-mesenchymal transition (EMT) markers including vimentin, fascin and β- catenin. The gene discussed is VIM; the disease is colorectal carcinoma.