At the age of 20 years, he developed an adrenal crisis and subsequently, he was diagnosed with Addison’s disease (cortisol 27 nmol/L, n.v. 150–680 nmol/L; ACTH > 440.4 pmol/L, n.v. 2–14 nmol/L, PRA 53 μg/L/h, n.v. 0.2–2.8 μg/L/h). Here, POMC is linked to acute adrenal insufficiency.