POMC and Adrenal insufficiency: Analysis of family members (Figure 2A) revealed three heterozygous asymptomatic female carriers of the mutation (mother, sister and her daughter) and a 6-year-old affected nephew with latent adrenal insufficiency (cortisol 132 nmol/L, n.v. 150–680 nmol/L; ACTH 78 pmol/L, n.v. 2–14 nmol/L, PRA 5.4 μg/L/h, n.v. 0.2–2.8 μg/L/h) and completely normal clinical and neurological status.