It has been demonstrated that PSD proteins, such as PSD-95, Homer, and Shank, are involved in schizophrenia pathophysiology and that their gene expression is modulated by antipsychotics based on the D2R affinity, dose, and duration of treatment, whereas the specific receptor profile beyond dopamine D2R antagonism may further contribute to modulate the pattern of gene expression changes [349]. The gene discussed is SHANK2; the disease is schizophrenia.