Finally, the involvement of 5HT1A in schizophrenia pathophysiology is also confirmed by an in vitro preclinical study in PC12 cells treated with clozapine: it is demonstrated a decrease in tyrosine hydroxylase levels, with subsequent reduction in dopamine levels, probably mediated by D2R and 5HT1A stimulation [107]. The gene discussed is DRD2; the disease is schizophrenia.