Pathological conditions not only modulate subunit composition, as demonstrated in a preclinical study in a PCP mice model that showed an increase in NR2A and NR2B NMDAR subunits [244] but also the complete composition of the PSD, resulting in morphological and functional modifications (e.g., spine loss in the auditory cortex in schizophrenia patients) [245,246]. The gene discussed is GRIN2B; the disease is schizophrenia.