PIK3CD and triple-negative breast carcinoma: Furthermore, fluphenazine hydrochloride is also able to decrease the expression of p44/42 ERK and phosphorylate AKT, involved in the RAS/RAF/MEK/ERK and PI3K/AKT/mTOR pathways, relevant for triple-negative breast cancer, resulting in the suppression of the growth and survival of cancer cells [531].