One group of sarcomas (20%) is characterized by specific genetic changes and typically simple karyotypes, such as specific chromosomal translocations (e.g., FUS::DDIT3 in myxoid liposarcoma [MLPS]) and oncogenic mutations (e.g., KIT mutation in gastrointestinal stromal tumor [GIST]). This evidence concerns the gene KIT and gastrointestinal stromal tumor.