Interestingly, Kawamoto et al. [46] showed that curcumin was not able to counteract LPS-induced cognitive impairment, sickness behavior and anxiety in TNFR-1 and TNFR-2 double knockout mice, thus, suggesting that curcumin protection against cognitive deficits requires TNFR2 activation. Here, TNFRSF1A is linked to Cognitive impairment.