Thus, our study identified new interactions involving EMT, ZEB1, and miRNAs wherein miR-139-5p and miR-200c-3p negatively regulated ZEB1 mRNA levels in the pharyngeal cancer cell line (FaDu) while miR-199b-5p upregulated them in the oral cancer cell line (HN13). The gene discussed is ZEB1; the disease is lip and oral cavity carcinoma.