NANOG and liver cancer: Interestingly, most of the mRNAs suppressed by ZEB1 upregulated stem cell-related genes, such as TrKb, which, when activated, morphologically modifies the cells [24] and is related to metastases in colorectal and liver cancer [25], and NANOG, which upon activation expresses a phenotype similar to that of CSC and is related to poor prognosis [26].