There was also a trend towards an increase in severe COVID-19 patients’ EVs expressing endothelial–leukocyte adhesion molecule 1 (E-selectin, CD62E) compared to the HCs’ EVs (p = 0.0586) with large size effects, when comparing the EVs’ CD62E expression between HCs and moderate and severe patients (Cohen’s d = 0.835) (Figure 3b,c). This evidence concerns the gene SELE and COVID-19.