Severe COVID-19 patients’ EVs displayed a trend of increasing levels of ACE and TMPRSS2 compared to HCs, and the size effect analysis displayed large differences between HCs vs. severe COVID-19 patients (ACE: t-test, p = 0.063, Cohen’s d = 1.025068 and TMPRSS2: t-test p = 0.0496, Cohen’s d = 0.856734; Figure 2d, Supplementary Figure SM1c,d). The gene discussed is TMPRSS2; the disease is COVID-19.