POMC and primary hypophysitis: As previously stated, the initial approach to suspected primary hypophysitis encompasses prompt endocrine workup and evaluation of the pituitary gland-related hormonal profile, including cortisol, ACTH, insulin-growth factor-1, growth hormone, estradiol/testosterone, follicle stimulating hormone/luteinizing hormone, free thyroxine, TSH, prolactin, and plasma/urine osmolality and electrolyte [12,13].