For instance, 13 switch genes, GPNMB, TH, CD59, COL4A1, ZBTB16, TSPAN15, DMD, LEF1, GPR3, UBE2V1, DPP10, NECTIN2, LGALS3BP, CDKN1A, SERPINA1, and DMP1 were linked to AD, PD, FTD, PD dementia, Creutzfeldt Jakob disease, and LBD (Table 1). The gene discussed is ZBTB16; the disease is Parkinson disease.