The top pathways implicated in loneliness were adherens junctions, TGF-β, FOXO, Hippo, PI3K-AKT, WNT, AGE-RAGE, acute myeloid leukemia, microRNAs in cancer, JAK-STAT, and endometrial cancer (Figure 3b). This evidence concerns the gene AKT1 and acute myeloid leukemia.