For instance, 13 switch genes, GPNMB, TH, CD59, COL4A1, ZBTB16, TSPAN15, DMD, LEF1, GPR3, UBE2V1, DPP10, NECTIN2, LGALS3BP, CDKN1A, SERPINA1, and DMP1 were linked to AD, PD, FTD, PD dementia, Creutzfeldt Jakob disease, and LBD (Table 1). The gene discussed is UBE2V1; the disease is Creutzfeldt Jacob disease.