For example, HLA-DRB5, ARHGAP15, COL4A1, RBM38, DMD, LGALS3BP, WSCD2, CYTH4, and CNTRL overlapped with known genetic variants in depression, reinforcing the idea that loneliness may increase disease susceptibility [106,107,108]. The gene discussed is HLA-DRB5; the disease is major depressive disorder.