RA patients with high circCDKN2B−AS_006 expression had increased serum CRP levels and ESR compared to RA patients with low circCDKN2B−AS_006 expression, whereas RA patients with high miR−1258 expression exhibited decreased serum CRP levels and ESR compared to RA patients with low miR−1258 expression. This evidence concerns the gene ESR1 and rheumatoid arthritis.