On the contrary, we found a negative correlation between HHLA2 tumor concentration factor 1 from principal component analysis containing: HGF, M-CSF, b-NGF, SCGF-b, IL-7, FGFbasic, G-CSF, PDGF-bb, VEGF, GM-CSF (Figure 7, Table 4), and trophic factors, which can be produced by colon tumor cells. This evidence concerns the gene CSF3 and colonic neoplasm.