Single cell analysis predicted the existence of an intermediate precursor of HE, which is apparently multipotent and produces several cell types including endothelial cells, hematopoietic cells, for the needs of developing embryos, and for adult haematopoiesis As shown, HE is characterized by accessibility of chromatin enriched for SOX, FOX, GATA, and SMAD motifs, as well as the expression of HSC precursor specification factor Runx1 [38]. The gene discussed is RUNX1; the disease is hereditary elliptocytosis.