Additionally, RT can also lead to immunogenic cell death (ICD) through effects that include the release of tumor antigens, exposure of heat shock proteins (HSPs) on the cell surface, release of calreticulin, and increased expression of MHCI, intracellular adhesion molecule 1 (ICAM1), and lymphocyte function–associated antigen 3 [40]. This evidence concerns the gene CALR and neoplasm.