As shown in Figure 3C, RGS5 protein expression was suppressed in NAFLD/NASH cells but was recovered effectively by resmetirom treatment, and the phosphorylation of both STAT3 and NF-κB, which were activated in NAFLD/NASH, was significantly attenuated by resmetirom treatment. The gene discussed is NFKB1; the disease is metabolic dysfunction-associated steatotic liver disease.