PINK1 and Parkinson disease: This correlates with the pathological condition in Parkinson’s disease, when, due to a deficiency of PTEN-induced kinase 1 (PINK1), there is a decrease in the basement membrane potential and an impairment of calcium homeostasis [61], leading to the vulnerability of neurons to the opening of a transitional permeability pore, followed by the death of nerve cells [62].