A previous study of TDP-43A315T ALS model and patients, has demonstrated that exposure to O3 significantly altered the expression profile of protein kinase B (Akt), signal transducer and activator transcription 3 (STAT3) phosphorylation, and hypothalamic neuropeptides, which led to a significant rise in metabolism and genes involve in thermogenesis [18]. Here, STAT3 is linked to amyotrophic lateral sclerosis.