G2E3 and amyotrophic lateral sclerosis: It has been reported that some ALS genes are involved in proteostasis (including COPS7A, USP35, TMEM175, and G2E3), mitochondrial metabolism (including ATP5D, ATP5H, and BCS1L) or gene expression and RNA metabolism (including ATXN3, ARID1B, TAF10, and PTBP2), and that decreased expression of NUP50 (a constrained gene encoding a nuclear pore basket protein) was connected with ALS in a transcriptome-wide association study [32].