Figure 3 shows the threefold expanded protein-protein interactions of 12 selected ALS-associated genes (RPSA, MAP1LC3A, GABARAPL2, SOD1, ALS2, VAPB, TUBA4A, DCTN1, SETX, C9orf72, VCP, and HNRNPL) visualized with k-mean clustering into five clusters. The gene discussed is ALS2; the disease is amyotrophic lateral sclerosis.