Recently, several fusion genes have been identified from RNA-Seq data of ALS patients, including TVP23C–CDRT4, AC090517.5–ZNF280D, MAILR–ATP6V1C1 and C8orf44–SGK3 by neighbor fusion as well as YAF2–RYBP by inter-chromosomal fusion [41]. This evidence concerns the gene RYBP and amyotrophic lateral sclerosis.