Figure 4 presents the protein-protein interaction network of all ALS-associated genes (ATG16L2, SCFD1, VAC15, VEGFA, KEAP1, KIF5A, FIG4, TUBA4A, SIGMAR1, SETX, ANXA11, HNRNPL, NEK1, C9orf72, VCP, RPSA, ATP5B, and SOD1) together with the predicted kinases (AKT1, CDK1, CDK2, CDK4, DNAPK, MAPK14, and ERK2) and transcription factors (MYC, RELA, ZMIZ1, ESR1 EGR1, YY1, TRIM28, TAF7, CHD1, and FOXA2) visualized with k-mean clustering into seven clusters. Here, SIGMAR1 is linked to amyotrophic lateral sclerosis.