The 24 molecular targets obtained which are relevant to ALS disease progression include: cyclooxygenase-2 (UniProt ID: P35354), angiotensin I-converting enzyme (UniProt ID: P12821), HLA class I histocompatibility antigen A-3 (UniProt ID: P04439), Dipeptidyl peptidase IV (UniProt ID: P27487), inhibitor of apoptosis protein 3 (UniProt ID: P98170), Mu opioid receptor (UniProt ID: P35372), delta opioid receptor (UniProt ID: P41143), disks large homolog 4 (UniProt ID:P78352), endothelin receptor ET-A (UniProt ID: P25101), and HMG-CoA reductase (UniProt ID: P04035). This evidence concerns the gene ACE and amyotrophic lateral sclerosis.