PRKDC and amyotrophic lateral sclerosis: The analysis of the existing network of 76 ALS-associated genes investigated in this work showed the involvement of MYC, RELA, YY1, TRIM28, EGR1, ESR1, ZMZ1, TAFT, CHD1, and FOXA2 transcription factors, and the kinases MAPK14, CDK1, CDK2, CDK4, DNAPK, and AKT1, as shown in Figure 1.