IER3 and gastric cancer: These investigators also evaluated TLR2 on human GC cell lines using DNA microarray-based expression profiling and showed that the TLR2-induced response to human gastric cancer cell growth was upregulated by six anti-apoptotic genes (BCL2A1, BCL2, BIRC3, CFLAR, IER3, TNFAIP3) and the downregulation of two tumor suppressor genes (PDCD4, TP53INP1) [20].