In another cohort of 48 patients with cryptogenic cholestasis, we showed a DIC history in 35% of cases, itching in 27%, neonatal jaundice in 21%, juvenile cholelithiasis in 17%, personal or family history of ICP in 13%; interestingly, pathogenic/likely pathogenic mutations were found in 10 (21%) probands for 13 mutations: 6 in ABCB11, 2 in ATP8B1, 2 in ABCB4, and 3 in TJP2. This evidence concerns the gene ABCB4 and cholestasis.