We analyzed the expression of nEGFR and other observed biomarkers (Ki-67, p53, cyclin D1, mEGFR, ABCG2) by immunohistochemical methods in 161 subjects divided into three groups: 59 subjects with healthy oral mucosa, 50 patients with premalignant changes (31 leukoplakias and 19 erythroplakias), and 52 patients with OSCC in all TNM stages. The gene discussed is CCND1; the disease is leukoplakia.