Although the results of studies on Ki-67 and HNSCC are conflicting, there are a larger number of studies indicating that overexpression of Ki-67 is associated with progression of OPMD and with a higher rate of locoregional recurrence as well as distant metastasis and worse OS, DFS, RFS, and MFS in patients with OSCC [28,29,30,31]. The gene discussed is MKI67; the disease is head and neck squamous cell carcinoma.