In the group of patients with premalignant changes, when comparing the percentage of Ki-67 proliferation index in relation to the presence of oral epithelial dysplasias, a statistically significant higher percentage of Ki-67 proliferation index was observed in the subgroup of high-grade dysplasias (median 18.87% with a range of 6% to 30.5%) compared with low-grade dysplasias (median 10.34% with a range of 1 to 20.6%) (p = 0.005). This evidence concerns the gene MKI67 and dysplastic oral keratinocyte.