EGFR and neoplasm: Recent studies suggest that EGF, H2O2, UV radiation, therapeutic agents, and ionizing radiation may cause translocation of EGFR to the nucleus, where nuclear EGFR (nEGFR) interacts with various transcription factors (cyclin D1, ABCG2/BCRP, Aurora kinase A, COX-2, gene regulator c-Myc, iNOS) and acts on the activation of numerous genes involved in cell proliferation, tumor progression, and DNA repair [7,8,9,10].