We analyzed the expression of nEGFR and other observed biomarkers (Ki-67, p53, cyclin D1, mEGFR, ABCG2) by immunohistochemical methods in 161 subjects divided into three groups: 59 subjects with healthy oral mucosa, 50 patients with premalignant changes (31 leukoplakias and 19 erythroplakias), and 52 patients with OSCC in all TNM stages. This evidence concerns the gene ABCG2 and leukoplakia.