TNF and myopia: In the PBS control group, −30 D LIM eyes had significantly higher TNF-α (p < 0.01) mRNA expression than the 0 D eyes did, whereas no significant differences were observed in the native- and Holo-LF-administered groups (Figure 4A), suggesting that native-LF and Holo-LF can reduce the inflammatory response of myopia progression in the sclera.