BGLAP and chronic obstructive pulmonary disease: MSC multipotency was tested by cellular differentiation assays and reported that AD-MSC from both COPD and non-COPD donors were equally able to differentiate into adipocytes and osteoblasts after 21 days of culture under stimulation with FABP4 (for adipocytes) or osteocalcin (for osteoblasts) (Figure 1a).