Among different angiocrine factors activated by NF-kB and involved in a positive feedback loop with ROS as previously mentioned [17,18], vascular cell adhesion molecule 1 (VCAM-1) [25,26], ICAM-1 [26,27], selectins, and cytokines are primarily involved in the development of endothelial dysfunction by starting the recruitment of inflammatory cells, like monocytes, neutrophils, leukocytes, and macrophages, and exacerbating the inflammatory response [20]. The gene discussed is ICAM1; the disease is endothelial dysfunction.