BCL2 and B-cell chronic lymphocytic leukemia: Over the past few years, several additional BCL2 mutations, e.g., D103Y directly disrupting the BH3 binding P4 pocket, have been observed in CLL patients, unveiling various cooperating mutational patterns with coexisting mutations and overexpression of the pro-survival proteins BCL-XL and MCL1 [13,14,20,21].