BCL2 and B-cell chronic lymphocytic leukemia: Similarly, Lucas et al., reported recurrent BCL2 mutations, including A113G, F104L, F104S, L119V, and G101A coexisting with G101V, and the internal tandem duplication p.Arg107_Arg110, in a cohort of 24 patients with venetoclax and ibrutinib-resistant CLL [21].