CA12 and neoplasm: To summarize the data obtained in the preclinical CRC tumor models, it can be stated that the models overall do reflect the specific characteristics of CRC regarding expression of CAs and hypoxia provided by the transcriptomic data (Figure 1b); i.e., CAIX and CAXII expression is largely positively correlated to hypoxia, even if not stringent, and both CAs can be occur in a co-expressed manner (Figure 1b).