Although the anti-inflammatory and immunoregulatory functions of TSG-6 have been observed in various neurological disorders, including acute brain injury due to trauma, ischemia or haemorrhage [14], the majority of these findings focussed on the role of this protein as mediator of the beneficial effects of MSCs, whereas knowledge of the endogenous or direct functions of TSG-6 is poor. The gene discussed is TNFAIP6; the disease is nervous system disorder.