More importantly, our findings are in agreement with the observation that TSG-6 mRNA and protein levels increase in the peri-infarct and infarcted brain tissue when compared to the contralateral hemisphere of ischemic stroke patients, as protein staining was associated with damaged neurons and inflammatory mononuclear cells 3 to 29 days after the insult [39]. The gene discussed is TNFAIP6; the disease is ischemic stroke.