Biochemical studies disclosed a decrease in antioxidant activity in animal sera and a reduction in the circulating biomarkers of relevance to prostate carcinogenesis, such as IL-6 and TNF-α, which significantly correlated with PCa grade [116] and VEGF, known to be associated with prostate tumor grade, metastasis, and prognosis [117]. The gene discussed is IL6; the disease is medical procedure.