Depletion of Fis1, for example, has been shown to induce mitochondrial elongation in HeLa cells and in Fis1-null mouse embryonic fibroblasts (MEFs) [97,98], but has no effect on mitochondrial morphology in HCT116 (human colorectal carcinoma) cells [99]. This evidence concerns the gene FIS1 and colorectal carcinoma.