According to previous studies, the heterogeneity of the molecular and gene abnormalities exist in Cushing’s syndrome or subclinical Cushing’s syndrome (SCS) [89], in which epigenetic regulatory mechanisms of CYP11B1 play an important role in cortisol overproduction. The gene discussed is CYP11B1; the disease is Cushing syndrome due to macronodular adrenal hyperplasia.