These data were in line with the autophagy gene expression profiles found in the GBM datasets that exhibit increased transcription of ATG genes and DRAM [32] as well as the increase of Lc3b autophagosomes following Hh hyperactivation, supporting the role of this signaling pathway as an activator of the autophagic process in a GBM-like condition. The gene discussed is DRAM1; the disease is glioblastoma.